Tomas Francis will make his return from injury when Exeter Chiefs resume their bid to defend their LV= Cup title on Sunday.
Head coach Rob Baxter takes his side to Rodney Parade to take on the Newport Gwent Dragons (2.30pm).
After back-to-back European Challenge Cup wins against Connacht and Bayonne in the past fortnight, Baxter has made 14 changes to his starting line-up.
Ian Whitten is the only player who started against Bayonne to also start this weekend, but even he has a new position as he lines up in the centre alongside Dragons old boy Adam Hughes.
Byron McGuigan and Brett Sturgess, who were replacemts last weekend, also start in South Wales.
There is a lot of experience in the backs as former Wales internationals Tom James and Ceri Sweeney are joined by Tongan ace Fetu'u Vainikolo and the long-serving Haydn Thomas.
Up front internationals Tom Johnson and Elvis Taione feature, with a first senior appearance of the season for England flanker Johnson after neck surgery.
But Francis' inclusion is good news for Baxter, who was without his two first-choice tighthead props for the final two European group-stage encounters.
Francis was struggling with a back injury and Moray Low was out with an ankle injury. Scotland international Low is expected to be fit next month.
Hooker Greg Bateman provides the experience on the bench, with six academy players waiting for a chance to show what they can do.Exeter Chiefs: McGuigan; Vainikolo, Whitten, Hughes, James; Sweeney, Thomas; Sturgess, Taione, Francis, Sexton, Carrick-Smith, Johnson, Simmonds, Skinner. Reps: Bateman, Woolmore, Stanley, Holmes, Conlon, Townsend, May, Bodilly
