Government departments have raised £139m since May 2010 by selling surplus properties in the South West.
Cabinet Office Minister Francis Maude announced that across the UK more than £1billion has been generated by selling property and land no longer required by the civil service.
The Government has also exited more than 1,000 leasehold and Private Finance Initiative (PFI) properties, saving a further £168m in the first six months of 2012/13 financial year alone in rent and running costs.
Properties sold in the South West include Derriford Business Park Units in Plymouth and Bodmin County Court in Cornwall.
Others put up for sale include Honiton Magistrates Court in East Devon.
In Plymouth, the former Land Registry offices at Plumer House, Crownhill, were sold for £2.1m. Annual running costs for the building were £392,000 in 2009-10.
Mr Maude said: "It's remarkable that the Government was paying for property that it just wasn't using. That kind of waste is always unacceptable – but is completely unjustifiable when we are trying to reduce the deficit and get ahead in the global race.
"Our strategy is to get out of expensive leases and concentrate on the properties we actually own. Since the General Election we have slashed wasteful spend on buildings and negotiated great money making deals. The £1billion pounds we have saved the taxpayer represents £60 for every working family."
